The clinical use of parasiticides is essential for controlling parasites in companion animals, but growing evidence of resistance raises concerns about long-term effectiveness. While some parasiticides, like imidacloprid and isoxazolines, have not yet shown resistance in companion animal parasites, others, such as pyrethroids and macrocyclic lactones, have documented cases of resistance, particularly in fleas, ticks, and heartworms. Given the rise in resistance and environmental concerns, the veterinary community must reconsider current broad-spectrum parasite prevention strategies to promote better stewardship and sustainability of these treatments. In this session, the current parasiticide landscape is discussed, including evidence for resistance and environmental impacts. Guidance is given on how to tailor parasiticide use for specific situations and educate clients on the need for parasiticide use while minimizing negative consequences.